Vhl GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Vhl
von Hippel-Lindau tumor suppressor
MGI:103223

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0005515	protein binding	IPI	J:94679
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:126834
Molecular Function	GO:0003711	transcription elongation factor activity	ISO	J:164563
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:126834
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	IDA	J:100984
Cellular Component	GO:0005737	cytoplasm	IDA	J:100984
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IPI	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:234716
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:234716
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	IDA	J:100984
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IDA	J:100984
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:100984
Cellular Component	GO:0014069	postsynaptic density	IEP	J:234716
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Cellular Component	GO:0014069	postsynaptic density	IDA	J:234716
Cellular Component	GO:0030891	VCB complex	ISO	J:155856
Cellular Component	GO:0030891	VCB complex	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:106926
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:106926
Biological Process	GO:0048593	camera-type eye morphogenesis	IGI	J:185536
Biological Process	GO:0048593	camera-type eye morphogenesis	IMP	J:185536
Biological Process	GO:0061073	ciliary body morphogenesis	IMP	J:185536
Biological Process	GO:0045446	endothelial cell differentiation	IMP	J:218695
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:106926
Biological Process	GO:0048069	eye pigmentation	IMP	J:185536
Biological Process	GO:0048877	homeostasis of number of retina cells	IMP	J:185536
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	IMP	J:218695
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	IMP	J:218695
Biological Process	GO:0061072	iris morphogenesis	IMP	J:185536
Biological Process	GO:0061072	iris morphogenesis	IGI	J:185536
Biological Process	GO:0006582	melanin metabolic process	IMP	J:185536
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	IMP	J:218695
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:185536
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP	J:218695
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP	J:218695
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP	J:218695
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:93322
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0030182	neuron differentiation	ISO	J:155856
Biological Process	GO:0003310	pancreatic A cell differentiation	IMP	J:218695
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:185536
Biological Process	GO:0010498	proteasomal protein catabolic process	IMP	J:141453
Biological Process	GO:0030163	protein catabolic process	IMP	J:84384
Biological Process	GO:0015031	protein transport	IDA	J:100984
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	IGI	J:93322
Biological Process	GO:0042069	regulation of catecholamine metabolic process	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:185536
Biological Process	GO:0099175	regulation of postsynapse organization	IPI	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IPI	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:234716
Biological Process	GO:0099175	regulation of postsynapse organization	IEP	J:234716
Biological Process	GO:0032880	regulation of protein localization	IMP	J:185536
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	IGI	J:93322
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	IGI	J:93322
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IEP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IDA	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:234716
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	IMP	J:234716
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0003309	type B pancreatic cell differentiation	IMP	J:218695

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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