GO Annotations Graph

• Symbol: Gbp2
• Name: guanylate binding protein 2
• ID: MGI:102772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0003925	G protein activity	ISO	J:164563
Molecular Function	GO:0019003	GDP binding	ISO	J:164563
Molecular Function	GO:0004382	GDP phosphatase activity	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISS	J:64689
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0030507	spectrin binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:314959
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:155210
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0106139	symbiont cell surface	ISO	J:164563
Cellular Component	GO:0106139	symbiont cell surface	IDA	J:236523
Cellular Component	GO:0020005	symbiont-containing vacuole membrane	IDA	J:155210
Cellular Component	GO:0012506	vesicle membrane	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	IMP	J:210626
Biological Process	GO:0044406	adhesion of symbiont to host	IDA	J:155210
Biological Process	GO:0035458	cellular response to interferon-beta	IDA	J:155210
Biological Process	GO:0035458	cellular response to interferon-beta	IDA	J:145965
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:208845
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:155210
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:155210
Biological Process	GO:0051715	cytolysis in another organism	IDA	J:231714
Biological Process	GO:0051715	cytolysis in another organism	IMP	J:210626
Biological Process	GO:0051715	cytolysis in another organism	IDA	J:231713
Biological Process	GO:0051715	cytolysis in another organism	IMP	J:208845
Biological Process	GO:0042742	defense response to bacterium	IMP	J:210626
Biological Process	GO:0042742	defense response to bacterium	IMP	J:208845
Biological Process	GO:0042742	defense response to bacterium	IDA	J:333172
Biological Process	GO:0042742	defense response to bacterium	IDA	J:231714
Biological Process	GO:0042742	defense response to bacterium	IDA	J:236523
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:155210
Biological Process	GO:0042832	defense response to protozoan	IBA	J:265628
Biological Process	GO:0042832	defense response to protozoan	IDA	J:155210
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	IDA	J:231714
Biological Process	GO:0140973	positive regulation of AIM2 inflammasome complex assembly	IDA	J:231713
Biological Process	GO:0140639	positive regulation of pyroptosis	IDA	J:333172
Biological Process	GO:0140639	positive regulation of pyroptosis	IMP	J:208845
Biological Process	GO:0140639	positive regulation of pyroptosis	IDA	J:231713
Biological Process	GO:0140639	positive regulation of pyroptosis	IDA	J:231714
Biological Process	GO:0006605	protein targeting	IDA	J:236523
Biological Process	GO:0009617	response to bacterium	IEP	J:190322