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H2-I Complex/Cluster/Region Detail
Summary
  • Symbol
    H2-I
  • Name
    H2 I region, includes H2-Aa, Ab, Bl, Ea, Eb, Eb2, Ob, Pb
  • Synonyms
    H-2I
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:95903
    NCBI Gene: 111861
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 17, Syntenic
  • Mapping Data
    4 experiments
Human Diseases
more
  • Diseases
    1 with H2-I mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-10387, MGD-MRK-10499
References
more
  • Summaries
    All 48
    Diseases 1
    Phenotypes 28
  • Earliest
    J:5712 Frelinger JA, et al., Effects of anti-Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A-reactive cells to the I-J subregion of the H-2 gene complex. J Exp Med. 1976 Oct 1;144(4):1141-6
  • Latest
    J:281514 Cebula A, et al., Dormant pathogenic CD4(+) T cells are prevalent in the peripheral repertoire of healthy mice. Nat Commun. 2019 Oct 25;10(1):4882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory