Tg(Myl2-IRS1*)7Shlm
Transgene Detail

Summary

• Symbol: Tg(Myl2-IRS1*)7Shlm
• Name: transgene insertion 7, Gerald Shulman
• MGI ID: MGI:3772658
• Synonyms: IRS1mtTg
• Transgene: Tg(Myl2-IRS1*)7Shlm Location: unknown
• Alliance: Tg(Myl2-IRS1*)7Shlm page

Transgene origin

• Strain of Origin: C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myl2-IRS1*)7Shlm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IRS1 (3667)

  Irs1	(MGI:99454)

• Mutation details: The transgene construct contains a human IRS1 cDNA incorporating Ser302Ala, Ser307Ala, and Ser612Ala mutations driven by a mouse myosin light chain 2 (Myl2) promoter with a human growth hormone tag. (J:142011)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142011 Morino K, et al., Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 2008 Oct;57(10):2644-51
• All: 1 reference(s)