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Timo
Other Genome Feature Detail
 Symbol
Name
ID
Timo
transgenic insertional mutants with obesity
MGI:3766098
Feature Type unclassified other genome feature
Genetic Map
Chromosome 2
Syntenic
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Transgenic(1)
 
Homozygous mice display severe obesity, polyphagia, increased fat and lean mass, increased aggression to other mice, elevated leptin, insulin, cholesterol, and glucose levels, insulin resistance, and impaired glucose tolerance. Hemizygous mice show obesity and elevated LDL cholesterol.
 
Human Diseases Modeled Using Mouse Timo (2)    Alleles Annotated to Human Diseases(1)   
References (Earliest) J:127183 Sha H, et al., Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice. Physiol Genomics. 2007 Oct 22;31(2):252-63
All references(2)
Disease annotation references (1)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory