Alcdp2 QTL Detail

Summary

• Symbol
  Alcdp2
• Name
  alcohol dependency 2
• Synonyms
  Calw2

• Feature Type
  QTL
• IDs
  MGI:3050454
  NCBI Gene: 100035572
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 19, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  100035572

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:91457 Buck KJ, et al., Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002 Apr;160(4):398-407
• Latest
  J:98587 Hitzemann R, et al., On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res. 2004 Oct;28(10):1437-48

Candidate Genes for Alcdp2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Scd1	Chr19:44382889-44396148 (-)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 19, candidate genes for Alcdp2 at 40 cM were identified with modest priority status. These candidate genes are Scd1 (43 cM), Shoc2, Prdx3 (50 cM), and 3 other yet unidentified expressed sequences (ESTs).
Shoc2	Chr19:53932737-54021564 (+)	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 19, candidate genes for Alcdp2 at 40 cM were identified with modest priority status. These candidate genes are Scd1 (43 cM), Shoc2, Prdx3 (50 cM), and 3 other yet unidentified expressed sequences (ESTs).