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T(7;18)50H Cytogenetic Marker Detail
Summary
  • Symbol
    T(7;18)50H
  • Name
    reciprocal translocation, Chr 7 and 18, Harwell 50
  • Synonyms
    T50H
  • Feature Type
    reciprocal chromosomal translocation
  • IDs
    MGI:103976
    NCBI Gene: 21267
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 18, cytoband B2
  • Mapping Data
    4 experiments
Human Diseases
more
  • Diseases
    1 with T(7;18)50H mouse models

Human Disease Mouse Models
       Prader-Willi Syndrome; PWS   OMIM: 176270 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 3 genetic backgrounds
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Radiation induced
    1
Mice heterozygous for this reciprocal translocation have reduced fertility. Unbalanced forms of this translocation comprising maternal or paternal duplication of Chr7 segments are used to study associated imprinted phenotypes.
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-25298
References
more
  • Summaries
    All 13
    Diseases 2
    Phenotypes 9
  • Earliest
    J:12947 Lyon MF, et al., The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice. Genet Res. 1964;5:448-467
  • Latest
    J:198496 Resnick JL, et al., Recommendations for the investigation of animal models of Prader-Willi syndrome. Mamm Genome. 2013 Jun;24(5-6):165-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory