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Mapping Data
  • Experiment
  • Chromosome
  • Reference
    J:121226 Vadasz C, et al., Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Neurochem Res. 2007 Jul;32(7):1099-112
  • ID
GeneAlleleAssay TypeDescription
Eac1 visible phenotype
Eac2 visible phenotype
Vmn1r49 reported elsewhere
Lrrtm1 reported elsewhere
Lrrtm4 reported elsewhere
Prokr1 reported elsewhere
Grm7 reported elsewhere
Gpr27 reported elsewhere
Tpra1 reported elsewhere
Lrrn1 reported elsewhere
Grip2 reported elsewhere
Chchd4 reported elsewhere
Eac3 visible phenotype
Camk1 reported elsewhere
Gnb3 reported elsewhere
Tas2r104 reported elsewhere
Tas2r105 reported elsewhere
Tas2r106 reported elsewhere
Tas2r107 reported elsewhere
Tas2r130 reported elsewhere
Tas2r102 reported elsewhere
Tas2r115 reported elsewhere
Tas2r120 reported elsewhere
Grin2b reported elsewhere
Soa reported elsewhere
Eac4 visible phenotype
Kcnj8 reported elsewhere
  • Experiment
    Linkage analysis was performed on male animals from a series of Recombinant QTL Introgression (RQI) strains (derived from BALB/cJ or CXBI donor DNA on a C57BL/6ByJ genetic background) to identify QTLs associated with alcohol consumption. Adult male animals from 43 B.C RQI strains and 35 B.I strains were analyzed using a 2-bottle choice test. Progenitor strains BALB/cJ and CXBI exhibit lower ethyl alcohol consumption (EAC) compared to progenitor strain C57BL/6ByJ. Three hundred ninety-six microsatellite markers were used for linkage analysis.

    Composite interval mapping identified several significant linkages to ethyl alcohol consumption on mouse Chromosome 6 at 36.5 cM (Eac1, LOD=3.6, P<0.001), 42.5 cM (Eac2, LOD=3.11, P<0.001), 62.2 cM (Eac3, LOD=2.09,P<0.01), and 73.5 cM (Eac4, LOD=3.28, P<0.001). C57BL/6ByJ-derived alleles at Eac1, Eac2, Eac3, and Eac4 confer increased ethyl alcohol consumption.

    The RQI donor block region for Eac1 and Eac2 spans 33.5 cM - 48.2 cM. Eila2 (36.5 cM), Etlm3 (30 cM), Rear1 (36.5 cM), Bits2 (37 cM), and Taste5 (48 cM) are previously identified behavior and preference QTLs mapping to this interval. Potential candidate genes for Eac1 and Eac2 include V1rb2 (37 cM), Lrrtm1, Lrrtm4, Grm7, Gpr175, Gpr27, Lrrn1, Prokr1 (formerly Gpr73), Grip2, and Chchd4.

    The RQI donor block for Eac3 spans 46 cM - 65.5 cM. Potential candidate genes found within this interval include Camk1 (48.7 cM), Gnb3 (60.19 cM), Tas2r104 (62 cM), Tas2r105 (62 cM), Tas2r106 (62 cM), Tas2r107 (62 cM), Tas2r130 (62 cM), Tas2r102 (63.4 cM), Tas2r115 (63.4 cM), Tas2r120 (63.4 cM), and Grin2b (64.5 cM). Previously identified behavior and preference QTLs located near Eac3 include Taste5(48.1 cM), Taste8 (49.5 cM), Qui (50.5 cM), Aaj3 (52.5 cM), Btts (63.3 cM),Mop1 (63.3 cM), Soa (63.4 cM), and Etohcta6 (63.6 cM).

    Kcnj8 at 70 cM is a potential candidate gene for Eac4.

    On mouse Chromosome 12, significant linkage to ethyl alcohol consumption mapped to 51 cM (Eac5, LOD=2.94, P<0.01) using composite interval mapping. The RQI donor block for Eac5 spans 46 cM - 58 cM. Marq4 is a previously identified QTL mapping to this interval and Calm1 is a potential candidate gene for Eac5. A suggestive locus named Eac6 (LOD=2.36, P<0.2), later confirmed by multiple interval mapping, is located at 21 cM. The RQI donor block spans 16 cM - 29 cM. Potential candidate genes for Eac6 include Prkch-rs1 (29 cM), and Stxbp6. Previously identified QTLs mapping to this locus include Rear2 (16 cM), Cocia1 (23 cM), Drb5 (25 cM), Aaq2 (27 cM), and Vacq7 (1 cM). C57BL/6ByJ-derived alleles at Eac5 and Eac6 confer increased ethyl alcohol consumption.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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