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Mapping Data
Experiment
  • Experiment
    TEXT-Physical Mapping
  • Chromosome
    5
  • Reference
    J:50926 Hough RB, et al., Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13800-5
  • ID
    MGI:1321227
Genes
GeneAlleleAssay TypeDescription
D5Buc2 overlapping clones, direct sequencing, PFGE
Pdgfra overlapping clones, direct sequencing, PFGE
D5Buc3 overlapping clones, direct sequencing, PFGE
D5Buc4 overlapping clones, direct sequencing, PFGE
D5Buc5 overlapping clones, direct sequencing, PFGE
Kit overlapping clones, direct sequencing, PFGE
Rw overlapping clones, direct sequencing, PFGE, visible phenotype
Ph overlapping clones, direct sequencing, PFGE, visible phenotype
En2
Notes
  • Experiment
    The authors used overlapping clones, direct sequencing, and PFGE to construct a physical map of the Rw and Ph mutations on mouse Chromosome 5. Rw mice were found to contain an inversion with the breakpoint of the inversion located within the Dpp6 gene. The order of markers in a normal mouse was found to be D5Buc2 - Pdgfra - D5Buc3 - D5Buc4 - D5Buc5 - Kit. The Pdgfra, D5Buc3 and D5Buc4 markers were missing in the Ph deletion. Based on PFGE analysis D5Buc5 is located 160-220 bps from Kit.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory