Inbred Strains
of Rats: SBH
Inbr. F20+.
Origin: "Sabra Hypertensive" Hebrew University Sabra
outbred rats with brother x sister mating and selection for high blood
pressure following unilateral nephrectomy and treatment with deoxycorticosterone
and sodium chloride (Ben-Ishay et al 1981, Ben-Ishay 1984,
Ben-Ishay and Yagli, 1994 who also reviews their characteristics).
Characteristics
SBH rats are generally heavier and their blood pressure is about 20mmHg
higher than SBN rats. Occasionally a measurable degree of spontaneous
hypertension is observed, but large differences are observed between SBH
and SBN following treatment with hypertension-inducing agents such as
chronic excess dietary sodium (
see also Mekler
et al 1985) or the clipping of one renal artery. The rats have a preference
for drinking saline compared with water and show a decreased diuretic
and natriuretic response to acute saline loading. Erythrocytes have an
increased passive permeability to sodium ions. The rats also show an enhanced
norepinephrine turnover and an impaired baroreflex function in young rats
which seems to precede the development of hypertension (
Ben-Ishay and Yagil, 1994, Yagil
et al, 1995, LeJossec et al, 1995a,b)
Ben-Ishay
D., Zamir N., Feuerstein G., Kobrin I., Le Quan-Bui K. H., and Devynck
M. A. (1981) Distinguishing traits in the Sabra hypertension-prone (SBH)
and hypertension-resistant (SBN) rats. Clin. Exp. Hyperten. 3,
737-747.
Ben-Ishay
D. and Yagil Y. (1994) The Sabra hypertension-prone and -resistant strains,
in Handbook of Hypertension Vol. 16 Experimental and Genetic Models
of Hypertension (Ganten D. and de Jong W., eds), pp. 272-299. Elsevier,
Amsterdam, New York, Oxford.
Ben-Ishay B.
(1984) The Sabra hypertension-prone and -resistant strains, in Handbook
of Hypertension Vol. 4. Experimental and genetic models of hypertension
(de Jong W., ed), pp. 296-313. Elsevier, Amsterdam, New York, Oxford.
Mekler
J., Yagil Y., and Ben-Ishay D. (1985) Renal response to acute saline loading
in Sabra hypertension-prone and -resistant rats. Experientia
41, 923-925.
Yagil Y.,
Lindpaintner K., Rubattu S., Ganten D., and Yagil C. (1995) The SBH/Y
and SBN/Y rats are free of genetic contamination and express a high-degree
of inter-strain genetic-polymorphism. Journal of the American Society
of Nephrology 6, 635.
INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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