PKD (reserved designation)

Inbr.F16 .

Colour: Albino

Genet. cy/+

Origin: Outbred Han:SPRD-cy/+ Sprague-Dawley rats from the Zentralinstitut fur Versuchstierkunde, Hannover, Germany to Dr. Bettina Kranzlin, Mannheim, Germany. Brother x sister inbreeding started in 1991.

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Characteristics

Develops polycystic kidney disease (Kaspareit-Rittinghausen et al, 1990) with cystic transformation of renal tubules as well as severe intersticial fibrosis (alterations of extracellular matrix) and inflammation (Gretz et al, 1996) due to an dominant gene designated PKDr1 on chromosome 5 (Bihoreau et al, 1997). Heterozygous rats have a moderate progression of the disease, while homozygotes have a rapid progression and die by about 3-4 weeks of age. There is uremia, protinuria, hyperlipidemia and hypertension in males older than 10 months. Clinical signs are seen in males at about 8 months, with death at 14-17 months and in females clinical signs are seen at 12 months and death is usually after 17 months of age. Liver and pancreatic cysts are common in females over 17 months of age (Kranzlin et al, 1997).

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Bihoreau M.-T., Ceccherini I., Browne J., Kranzlin B., Romeo G., Lathrop G. M., James M. R., and Gretz N. (1997) Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy/+rat. Hum. Mol. Genet. 6, 609-613.

Gretz N., Kranzlin B., Pey R., Schieren G., Bach J., Obermuller N., Ceccherini I., Kloting I., Rohmeiss P., Bachmann S., and Hafner M. (1996) Rat models of autosomal dominant polycystic kidney disease. Nephrol. Dial. Transplant. 11 (Suppl. 6), 46-51.

Kaspareit-Rittinghausen J., Deerberg F., Rapp K. G., and Wcisio A. (1990) A new rat model for polycystic kidney disease in humans. Transplant. Proc. 22, 2582-2583.

Kranzlin B., Schieren G., and Gretz N. (1997) Azotemia and extrarenal manifestations in old female Han:SPRD (cy/+) rats. Kidney International 51, 1160-1169.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK