P77PMC

Inbr.>20.

Colour: Albino,

Genet. c.

Origin: Wistar rats from Beijing Medical College in 1977.

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Characteristics

70% incidence of audigenic seizures, and also susceptible to the development of hyperthermia-induced (45^oC) convulsions, after which they are resistant to audiogenic seizures but still more susceptible to kainate-induced limbic seizures than controls (Zhao et al 1985). Cholecystokinin octapeptide (CCK-8) decreases seizure susceptibility with a depression of release of K+-stimulated GABA in cerebral cortex synaptosomes (Wu and Lin, 1992, Zhang et al, 1992). A low cerebral content of CCK-8 may account for the high susceptibility to audiogenic seizures (Zhang et al, 1993, Chen et al, 1994)

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Chen X. H., Han J. S., and Huang L. T. (1994) Cck receptor antagonist L-365,260 potentiated electroacupuncture analgesia in Wistar rats but not in audiogenic epileptic rats. Chinese Medical Journal 107, 113-118.

Wu X. R. and Lin P. X. (1992) Effects of cholecystokinin octapeptide on genetically-determined seizure susceptibility. Chinese Medical Journal 105, 110-115.

Zhang L. X., Wu M., and Han J. S. (1992) Suppression of audiogenic epileptic seizures by intracerebral injection of a CCK gene vector. Neuroreport 3, 700-702.

Zhang L. X., Zhou Y., Du Y., and Han J. S. (1993) Effect of CCK-8 on audiogenic epileptic seizure in P77PMC rats. Neuropeptides 25, 73-76.

Zhao D., Wu X., Pei Y., and Zuo Q. (1985) Long-term effects of febrile convulsions on seizure susceptibility in P77PMC rat-resistant to acoustic stimuli but susceptible to kainate-induced seizures. Exp. Neurol. 88, 688-695.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK