ODU

Inbr.F32.

Colour: Albino.

Genet. c.

Origin: From outbred Wistar Kyoto stock inbred by N Ito, Osaka Dental University. Selected for susceptibility to development of dental plaque (Ito et al 1975). To NIH in 1977 at F3 (Hansen et al 1982).

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Characteristics

Formation of dental plaque independent of type of diet fed (Ito et al 1977). Azuma et al (1978, 1979) have shown that the strain is useful for studying the relationship between dental plaque bacterial flora, especially Corynebacterium, and gingivitis. Several other bacteria involved in plaque formation, including species of genera Streptococcus, Viellonella, Neisseria, Staphylococcus, Bacteriodes, Leptotrichia, Fusobacterium, Actinomyces, Nocardia, and Diphtheroides (Ito et al 1975, Azuma et al 1979). Rat plaque differs from human plaque in content of extractable hexose, inorganic salts, and amino acid composition (Azuma et al 1978). Excellent reproductive performance.

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Azuma Y., Ito N., Shinohara M., and Mori M. (1978) Experimental gingivitis in ODU plaque-susceptible rats. II. Biochemical nature of the rat plaque. J. Periodontol. 49, 60-63.

Azuma Y., Shinohara M., Ito N., and Mori M. (1979) Experimental gingivitis in ODU plaque-susceptible rats. III. Toxic activity of the rat dental plaque. J. Periodontol. 50, 416-418.

Hansen C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents: (1980). Catalogue. NIH Publ. No. 83-606. Department of Health and Human Services, Washington, D.C.: U.S.

Ito N., Azuma Y., and Mori M. (1975) Experimental gingivitis: Development of a new strain of plaque-susceptible rat. J. Dental Res. 54, 425.

Ito N., Shinohara M., Azuma Y., and Mori M. (1977) Experimental gingivitis in ODU plaque-susceptible rats. I. Changes of plaque formation and body weight. J. Periodontol. 48, 201-208.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK