MWF

Inbr. ?.

Colour: Albino.

Genet. c.

Origin: From outbred Wistar rats selected for large numbers of superficial glomeruli.

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Characteristics

Short pentobarbitone sleeping time im males (2/10), Vieregge et al 1987). Males develop spontaneous systemic hypertension and proteinuria of glomerular origin, and glomerularsclerosis. Females develop less severe hypertension and have normal urinary protein excretion rate and no glomerularsclerosis (Remuzzi et al, 1992, Eisenberger et al, 1995).

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Eisenberger U., Fels L. M., Olbricht C. J., and Stolte H. (1995) Cathepsin-B and cathepsin-L in isolated proximal tubular segments during acute and chronic proteinuria. Renal Physiology and Biochemistry 18, 89-96.

Remuzzi A., Puntorieri S., Alfano M., Macconi D., Abbate M., Bertani T., and Remuzzi G. (1992) Pathophysiologic implications of proteinuria in a rat model of progressive glomerular injury. Lab. Invest. 67, 572-579.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK