MAXX

Inbr. F20+?.

Colour: Black hooded.

Genet. a, h.

Origin: from a cross of BNxLEW with subsequent inbreeding.

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Characteristics

Like strain BN, but in contrast to 17 other strains MAXX is susceptible to the development of mercury-induced autoimmunity to renal basement membranes with the development of membraneous glomerulonephritis (Henry et al 1988). Used to study alloantigen Eag-1 (Blankert et al 1987).

MF

See APR

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Blankert J. J., Muizert Y., van Es L. A., and Paul L. C. (1987) Cellular requirements for the induction of a humoral immune response to the endothelial alloantigen Eag-1. Transplant. Proc. 19, 3151-3152.

Henry G. A., Jarnot B. M., Steinhoff M. M., and Bigazzi P. E. (1988) Mercury-induced renal autoimmunity in the MAXX rat. Clin. Immunol. Immunopathol. 49, 187-203.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK