LER

Inbr. F30 (NIH 1989).

Colour: Albino.

Genet. c.

Origin: Originally designated Le-R and thought to be a mutation within LEW conferring resistance of experimental allergic encephalomyelitis (EAE) (Waxman et al, 1981, Driscoll et al 1985, Gasser et al, 1983). However, it now appears to have been an accidental genetic contamination by BUF/N rats (Goldmuntz et al, 1993),. See LEW, Immunology.

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Characteristics

Resistant to the induction of EAE, though susceptible to adoptively transferred EAE when they are injected with encephalitogenic T cells from EAE-susceptible LEW rats (Blankenhorn et al, 1995).

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Blankenhorn E. P., Stranford S. A., Martin A. M., and Hickey W. F. (1995) Cloning of myelin basic protein-reactive T-cells from the experimental allergic encephalomyelitis-resistant rat strain, LER. J. Neuroimmunol. 59, 173-183.

Driscoll B. F., Kies M. W., and Alvord J. E. C. (1985) The nature of the defect in experimental allergic encaphalomyelitis (EAE)-resistant Lewis (Le-R) rats. J. Immunol. 134, 1567-1570.

Gasser D. L., Hickey W. F., and Gonatas N. K. (1983) The genes for nonsusceptibility to EAE in the Le-R and BH strains are not linked to RT1. Immunogenet. 17, 441-444.

Goldmuntz E. A., Wilder R. L., Goldfarb Y., Cash J. M., Zha H. B., Crofford L. J., Mathern P., Hansen C. T., and Remmers E. F. (1993) The origin of the autoimmune disease-resistant LER rat - an outcross between the Buffalo and autoimmune disease-prone Lewis inbred rat strains. J. Neuroimmunol. 44, 215-219.

Waxman F. J., Perryman L. E., Hinrichs D. J., and Coe J. E. (1981) Genetic resistance to the induction of experimental allergic encephalomyelitis in Lewis rats. I. Genetic analysis of an apparent mutant strain with phenotypic resistance to experimental allergic encephalomyelitis. J. Exp. Med. 153, 61-74.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK