FHH and FHR (reserved symbol)

Inbr. F16 (Brown et al, 1996).

Colour: Fawn Hooded.

Genet. a, h, r.

Origin: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria. The colony was transferred to Erasmus University.

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Characteristics

Developes focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at a young age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al, 1966)

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Brown D. M., Provoost A. P., Daly M. J., Lander E. S., and Jacob H. J. (1996) Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genet. 12, 44-51.

Simons J. L., Provoost A. P., Anderson S., Troy J. L., Rennke H. G., Sandstrom D. J., and Brenner B. M. (1993) Pathogenesis of glomerular injury in the Fawn-Hooded rat - early glomerular capillary hypertension predicts glomerular sclerosis. Journal of the American Society of Nephrology 3, 1775-1782.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK