CRDH (Reserved symbol)

Inbr.Approx. 18 (1995).

Colour: Albino .

Genet. c.

Origin: As C ohen R osenthal D iabetic H ypertensive, from a cross between strains CDR and SHR followed by selection for high blood pressure and blood glucose levels following two-months of feeding a copper-poor, high (74%) sucrose diet. Selected animals were brother x sister mated (Cohen et al, 1993, Rosenthal et al 1995).

Characteristics:

Non-insulin-dependent overt diabetes: blood glucose 384_134 mg/dl (plasma insulin at 60 min following intragastric glucose load 83.3_10.2mU/mL) and hypertension blood pressure 176_8mm Hg. There was severe diffuse diabetic glomerulosclerosis and severe hypertensive changes in arteries and arterioles characterised by fibrinoid necrosis and/or "onion skin" lesions as well as smooth muscle hyperplasia. Myocardial changes were prominent, with foci of ischemic necrosis and hyperplastic vascular changes (see above references).

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Cohen A. M., Rosenmann E., and Rosenthal T. (1993) The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathological findings. AJH 6, 989-995.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK