BDE

Inbr. F27+.

Colour: Black hooded.

Genet: a, h.

Origin: Zentralinstitut fur Versuchstierzucht, Hannover, from a cross between BDVII and E3, with selection for black hooded offspring.

---

Characteristics

Low incidence of megaoesophagus/aperistalsis and microphthalmia. Animal model for adenosine-induced bronchoconstriction (Pauwels and van der Straeten 1987, Pauwels et al, 1993). Tachykinins cause bronchoconstriction in susceptible F344 mainly by an indirect mechanism that involves stimulation of NK1 receptors and mast cell activation, in contrast with the less sensitive strain BDE where they cause bronchoconstriction by a direct effect on the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994).

Used to test efficiency of AL-1576 in preventing naphthalene-induced cataract (Hockwin et al 1984).

---

Hockwin O., Wegner A., Sisk D. R., Dohrmann B., and Kruse M. (1984) Effect of AL-1576 in preventing naphthalene cataract in three rat strains. A slit lanp and scheimpflug photographic study. Lens Research 2, 321-335.

Joos G. F., Kips J. C., and Pauwels R. A. (1994) In-vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in 2 inbred rat strains. American Journal of Respiratory and Critical Care Medicine 149, 1160-1166.

Pauwels R. A. and van der Straeten E. (1987) An animal model for adenosine-induced bronchoconstriction. An. Rev. Respir. Dis. 136, 374-378.

Pauwels R., Joos G. F., Kips J. C., and Peleman R. A. (1993) Mechanisms of adenosine-induced bronchoconstriction - an animal-model. Drug Development Research 28, 318-321.

---

INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK