ALB

Inbr. F87 (Hok).

Colour: Dilute brown.

Genet. a, b, d, C, H.

Origin: Wolf and Wright, Albany Medical College in an attempt to develop a strain with a high incidence of spontaneous tumours, to NIH in 1950. No inbreeding records prior to transfer.

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Characteristics

Docile behaviour. About 10% mammary fibroadenomas (Wright et al 1940). Variable frequency of foetal resorption which affects reproductive performance (Hansen et al 1973). Low hepatic metabolism of anilene in females (10/10) (Page and Vesell 1969). Poor reproductive performance (11/12) and small litter size (10/12) (Hansen et al 1973). High 10-week body weight in males (22/23) (Tanase et al 1982).

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Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalogue of NIH Rodents. DREW Publ. No. 74-606. Department of Health, Education, and Welfare, Washington, D.C.: U.S.

Page J. G. and Vesell E. S. (1969) Hepatic drug metabolism in ten strains of Norway rat before and after pretreatment with phenobarbital. Proc. Soc. Exp. Biol. Med. 131, 256-261.

Tanase H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 4, 864-872.

Wright A. W., Klinck G. H. Jr., and Wolfe J. M. (1940) The pathology and pathogenesis of mammary tumors occurring spontaneously in the Albany strain of rats. Am. J. Pathol. 16, 817-834.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK