A28807.

Inbr. F49 (NIH 1989).

Colour: Pink-eyed dilute hooded, .

Genet: h, p.

Origin: Curtis and Dunning in 1936 as a subline of A7322 derived from a half-brother x sister mating at F15. To NIH in 1977 at F25 (Hansen et al 1982).

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Characteristics

Poor survival to 2-years in males, 50% (rank 3/5) and in females 55% (rank 3/5) with minimal chronic renal disease (Solleveld and Boorman 1986). Very docile. Susceptible to the induction of autoimmune thyroiditis (Penhale et al 1975a,b). Low and intermediate antibody responses to 1 and 10 g BSA, respectively (Armerding et al 1974a). Low antibody response to streptococcal group A carbohydrate; not linked to the MHC (Stankus and Leslie 1976). High relative heart weight in 10-week old males (20/23) (Tanase et al 1982).

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Armerding D., Katz D. H., and Benacerraf B. (1974a) Immune response genes in inbred rats. I. Analysis of responder status to synthetic polypeptides and low doses of bovine serum albumin. Immunogenet. 1, 329-339.

Hansen C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents: (1980). Catalogue. NIH Publ. No. 83-606. Department of Health and Human Services, Washington, D.C.: U.S.

Penhale W. J., Farmer A., and Irvine W. J. (1975a) Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum. Clin. Exp. Immunol. 21, 362-375.

Stankus R. P. and Leslie G. A. (1976) Rat interstrain antibody response and crossidiotypic specificity. Immunogenet. 3, 65-73.

Tanase H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred strains of rats. Part 1. Genetic determination of the development of cardiovascular enlargement in rats. Hypertension 4, 864-872.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK