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Inbred Strains of Mice: VY


Inbr (Nctr) 74. Variable yellow to agouti and black: Avy/a, a/a. Origin: The Avy mutation occurred in C3H/HeJ in 1960. Crossed with a C57BL/6J male, then backcrossed to C57BL/6J. One N3 male and two N1 females from M.M.Dickie, Jackson Lab. to Inst. Cancer Research in 1962. These were mated and the offspring sib mated. Maintained by Avy/a, a/a matings since then. To the Nctr in 1972 at F35. Caesarian derived and fostered on C3Hf in 1977 at F47. Pseudoagouti phenotype about 10% of Avy/a mice. Spontaneous hepatocellular tumours in 24% of male yellow mice but only 13% of black mice. Phenotypically yellow mice differ from agouti ones in a range of biological properties (Wolff et al 1990). Maint. by Nctr.

Wolff G. L., Greenman D. L., Frigeri L. G., Morrissey R. L., Suber R. L., and Felton R. P. (1990) Diabetogenic response to streptozotocin varies among obese yellow and among lean agouti (BALB/c x VY)F1 hybrid mice. Proc. Soc. Exp. Biol. Med. 193, 155-163. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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