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Inbred Strains of Mice: SWXL


Inbr. ?. Set of 7 recombinant inbred strains maintained at the Jackson Laboratory.

SWXL-4 mice exhibit tonic-clonic and generalised seizures similar to the commonest epilepsy in humans. Seizures are observed in routine handling from about 80 days of age, and are due to a dominant gene Szf1 on chromosome 7 which accounts for about 32% of the variation in susceptibility (Frankel et al, 1994).

Frankel W. N., Taylor B. A., Noebels J. L., and Lutz C. M. (1994) Genetic epilepsy model derived from common inbred mouse strains. Genetics 138, 481-489. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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