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Inbred Strains of Mice: SWV


Inbr (Bc) 73. Albino: A,c, plus unknown dilution gene. Origin: Outbred animals from Defense Research Bd. Suffield, Alberta to Cent. Animal Depot, Univ. Brit. Columbia. Inbreeding started in 1959. Develops nephrogenic diabetes insipidus with a progressive and unique kidney defect. Maint. by Bc.


Females over 8 months have a hereditary polydipsia-polyuria defect with a severe increase in water turnover and with hypotonic urine that contains no glucose, blood or protein: i.e. nephrogenic diabetes insipidus. They are vasopressin-resistant. Females also have a progressive kidney defect which, although it resembles nephronophthisis in some aspects and hypokalaemia in others, is unique. Males have a milder form of the defect at an older age and show no signs of histopathology (Virgo and Miller, 1974). Resistant to acetazolamide-induced teratogenesis (Hackman and Hurley 1983).

Hackman R. M. and Hurley L. S. (1983) Interaction of dietary zinc, genetic strain, and acetazolamide in teratogenesis in mice. Teratology 28, 355-368. \par

Virgo N. S. and Miller J. R. (1974) Hereditary vasopressin-resistant diabetes insipidus in SWV mice. Can. J. Physiol. Pharmacol. 52, 995-1011. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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