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Inbred Strains of Mice: SSIN


Inbr (Utsp) 22+. Albino. Origin: 1970's, from outbred SENCAR (sensitive to carcinogens) selected for high skin tumour number following challenge for 10 generations with a topical application of dimethylbenz(a)anthracene followed by repetitive application of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Inbred in 1986.


Hardy animals with low spontaneous tumour incidence; useful in chemical carcinogenesis studies because of extreme sensitivity to TPA (Fischer et al 19870 1987). Low LD50 following injection of butylated hydroxytoluene (BHT) (4/4) (Kehrer and DiGiovanni 1990) \par \par

Fischer S. M., O'Connell J. F., Conti C. J., Tacker K. C., Fries J. W., Patrick K. E., Adams L. A., and Slaga T. J. (1987) Characterization of an inbred strain of the SENCAR mice that is highly sensitive to phorbol esters. Carcinogenesis 8, 421-424. \par

Kehrer J. P. and DiGiovanni J. (1990) Comparison of lung injury induced in 4 strains of mice by butylated hydroxytoluene. Toxicol. Lett. 52, 55-61. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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