of Mice: SHN
Inbr: F51 (Mei). Genet: c, A, b.
Origin: Swiss albino mice from
the City of Hope Medical Centre, California. Inbred as SWM/Ms by Natl.
Inst. Genet. Misima. Selected for high early mammary tumour incidence
with full-sib mating starting in 1964, and F20 in 1972.
Have mammary tumour virus locus Mtv4
which is genetically transmitted
rather than being passed through the milk (Imai
et al 1983
0 1983). Tumour incidence 90-100% in breeders and virgins
at 6.6 months. Litter size 7.6, weaning rate 89% (Nagasawa et al., 1976a
, 1976a, b). See also SLN.
Imai S., Tsubura
Y., Hilgers J., and Michalides R. (1983) A new locus (Mtv-4) for endogenous
mammary tumor virus expression and early mammary tumor development in
the SHN mouse strain. J. Natl. Cancer Inst. 71, 517-521.
H., Tokuzen R., and Nakahara W. (1976a) Growth of mammary tumors in a
high and a low mammary tumor strains of mice established from the same
basal stock of Swiss albino. Gann 67, 913-915.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,