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Inbred Strains of Mice: SHN


Inbr: F51 (Mei). Genet: c, A, b. Origin: Swiss albino mice from the City of Hope Medical Centre, California. Inbred as SWM/Ms by Natl. Inst. Genet. Misima. Selected for high early mammary tumour incidence with full-sib mating starting in 1964, and F20 in 1972.


Have mammary tumour virus locus Mtv4 which is genetically transmitted rather than being passed through the milk (Imai et al 19830 1983). Tumour incidence 90-100% in breeders and virgins at 6.6 months. Litter size 7.6, weaning rate 89% (Nagasawa et al., 1976a, 1976a, b). See also SLN.

Imai S., Tsubura Y., Hilgers J., and Michalides R. (1983) A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain. J. Natl. Cancer Inst. 71, 517-521.

Nagasawa H., Tokuzen R., and Nakahara W. (1976a) Growth of mammary tumors in a high and a low mammary tumor strains of mice established from the same basal stock of Swiss albino. Gann 67, 913-915.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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