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Inbred Strains of Mice: SEC


Pale brown: a,b,cch. Origin: Green prior to 1946 from a cross between NB and BALB/c. Carries se (short-ear) gene causing short ears and skeletal abnormalities. Substrains as follows:


Inbr (Rl) 100 +. Colour ?: a,b,cch,d,se .Origin: E.L.Green 1948 to Rl at F20-F21. Maint. by J. \par


Inbr (Le) 149. Gets multiple lung cysts, especially in se/se. \par


Inbr (J) 138. From SEC/1Gn, but short-ear eliminated by E.S.Russell.


High shuttle-box avoidance (2/5) (Messeri et al., 1972., 1972). High plasma cholinesterase activity (7/22 in females, 2/22 in males) (Angel et al., 1967., 1967). High hepatic delta-aminolaevulinic acid synthetase activity after DDC treatment (3/15) (Gross and Hutton, 1971). Low sensitivity of females to X-irradiation (5/5) (Ehling, 1964). Low lymphocyte phytohaemagglutinin response (31/43) (Heiniger et al., 1975., 1975). Good reproductive performance (1/5) (Ehling, 1964).

Angel C. R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability of plasma cholinesterase activity in inbred mouse strains. Science 156, 529-530. \par

Ehling U. H. (1964) Strain variation in reproductive capacity and radiation response of female mice. Radiation Res. 23, 603-610. \par

Gross S. and Hutton J. (1971) Induction of hepatic -aminolaevulinic acid synthetase activity in strains of inbred mice. J. Biol. Chem. 246, 606-614. \par

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831. \par

Messeri P., Oliverio A., and Bovet D. (1972) Relations between avoidance and activity. A diallel study in mice. Behav. Biol. 7, 733-742. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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