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Inbred Strains of Mice: SB


Inbr (Le) 101. Pale grey. sa,bg,Aw. Origin: mutations to sa and bg, possibly rediation-induced, occurred independently in stocks used for mutation rate studies at Oak Ridge. Rl to Le 1961, then sib-mated.


Develops progressive infectious pneumonitis associated with the beige gene. Also has a high incidence of lymphadenopathy, including reticulum cell neoplasms and atypical lympho-proliferative lesions. Beige mice have giant lysosomal granules in the leukocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle. These mice appear to be a suitable model for the study of the increased susceptibility to infection seen with this syndrome (Lane and Murphy, 1972).

Lane P. W. and Murphy E. D. (1972) Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72, 451-460. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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