of Mice: SB
Inbr (Le) 101. Pale grey. sa,bg,Aw.
Origin: mutations to sa
occurred independently in stocks used for mutation rate studies at Oak
Ridge. Rl to Le 1961, then sib-mated.
Develops progressive infectious pneumonitis associated with the beige
gene. Also has a high incidence of lymphadenopathy, including reticulum
cell neoplasms and atypical lympho-proliferative lesions. Beige mice have
giant lysosomal granules in the leukocytes and pigment dilution closely
analogous to the Chediak-Higashi syndrome in man and similar disorders
in mink and cattle. These mice appear to be a suitable model for the study
of the increased susceptibility to infection seen with this syndrome (Lane and Murphy, 1972
Lane P. W.
and Murphy E. D. (1972) Susceptibility to spontaneous pneumonitis in an
inbred strain of beige and satin mice. Genetics 72, 451-460.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,