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Inbred Strains of Mice: SAMP6


Inbr ?+56. Origin: as SAMP1. Albino (c).


Shows accelerated aging (Takeda et al 1991). Has a significantly lower peak bone mass than other SAMP strains, but rate of decrease is similar to other strains. Mineral and collagen contents per dry weight of bone show little difference between strains. This suggests that osteopenia is not due to osteomalacia but rather to osteoporosis (Matsuchita et al 1986). Median survival is 321 days in conventional conditions.

Matsuchita M., Tsuboyama T., Kasai R., Okumura H., Yamamuro T., Higuchi K., Higuchi K., Kohono A., Yonezu T., Utani A., Umezawa M., and Takeda T. (1986) Age-related changes in bone mass in the senescence accelerated mouse (SAM): SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am. J. Pathol. 125, 276-283. \par

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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