SAMP3

Inbr ?+56. Origin: as SAMP1. Albino (c).

Characteristics:

Shows accelerated aging (Takeda et al 1991). The first of the SAMP series to show degenerative changes in the condyle of the temporomandibula joint, reaching approx 50% at 7-9 months and 100% at over 12 months (Chen et al 1989). Median survival time is 507 days in conventional conditions.

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Chen W. H., Hosokawa M., Tsuboyama T., Ono T., Iizuka T., and Takeda T. (1989) Age-related changes in the temporomandibular joint of the senescence accelerated mouse (SAM): SAM-P/3 as a new murine model of degenerative joint disease. Am. J. Pathol. 135, 379-385.

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK