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Inbred Strains of Mice: SAMP3


Inbr ?+56. Origin: as SAMP1. Albino (c).


Shows accelerated aging (Takeda et al 1991). The first of the SAMP series to show degenerative changes in the condyle of the temporomandibula joint, reaching approx 50% at 7-9 months and 100% at over 12 months (Chen et al 1989). Median survival time is 507 days in conventional conditions.

Chen W. H., Hosokawa M., Tsuboyama T., Ono T., Iizuka T., and Takeda T. (1989) Age-related changes in the temporomandibular joint of the senescence accelerated mouse (SAM): SAM-P/3 as a new murine model of degenerative joint disease. Am. J. Pathol. 135, 379-385. \par

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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