of Mice: SAMP2
Inbr. ?+62. Origin: as SAMP1. Albino (c
Shows accelerated aging (Takeda et al 1991
All mice over 7 months have amyloidosis in which AApoAII often co-exists
with AA amyloid protein (Higuchi et al 1983
The incidence of contracted kidney is about 73% at over 10 months of age.
Median survival is 304 days in conventional conditions.
Appears to be a suitable model for studies of senile lung (Teramoto et al, 1994).
K., Matsumura A., Honma A., Takeshita S., Hashimoto K., Hosokawa M., Yasuhira
K., and Takeda T. (1983) Systemic senile amyloid in senescence-accelerated
mice: A unique fibril protein demonstrated in tissue from various organs
by the unlabelled immunoperoxidase method. Lab. Invest. 48,
T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM):
A novel murine model of accelerated senescence. J. Amer. Geriatr.
Soc. 39, 911-919.
S., Fukuchi Y., Uejima Y., Teramoto K., Oka T., and Orimo H. (1994) A
novel model of senile lung: Senescence-accelerated mouse (SAM). American
Journal of Respiratory and Critical Care Medicine 150, 238-244.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,