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Inbred Strains of Mice: SAMP2


Inbr. ?+62. Origin: as SAMP1. Albino (c)


Shows accelerated aging (Takeda et al 1991). All mice over 7 months have amyloidosis in which AApoAII often co-exists with AA amyloid protein (Higuchi et al 1983). The incidence of contracted kidney is about 73% at over 10 months of age. Median survival is 304 days in conventional conditions.

Appears to be a suitable model for studies of senile lung (Teramoto et al, 1994).

Higuchi K., Matsumura A., Honma A., Takeshita S., Hashimoto K., Hosokawa M., Yasuhira K., and Takeda T. (1983) Systemic senile amyloid in senescence-accelerated mice: A unique fibril protein demonstrated in tissue from various organs by the unlabelled immunoperoxidase method. Lab. Invest. 48, 231-240. \par

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919. \par

Teramoto S., Fukuchi Y., Uejima Y., Teramoto K., Oka T., and Orimo H. (1994) A novel model of senile lung: Senescence-accelerated mouse (SAM). American Journal of Respiratory and Critical Care Medicine 150, 238-244. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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