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Inbred Strains of Mice: SAMP10

SAMP10

Inbr ?+50. Origin: as SAMP1. Albino (c).

Characteristics:

Shows accelerated aging.All mice over 8 months have amyloidosis and about 78% of mice over 10 months have contracted kidneys. Median survival time in conventional conditions is 333 days. (Takeda et al 1991). Spontaneous brain atrophy with advancing age. This is most marked in the frontal cortex, and other neocortical regions develop diffuse atrophy. Age-related loss of neocortical neurones is evident (Shimada et al 1992), and correlates with deficits in learning (Shimada et al 1993). Aged garlick oil prevents the development of atrophic changes in the frontal brain at 12 months (Moriguchi et al, 1997).


Moriguchi T., Saito H., and Nishiyama N. (1997) Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model. Clin. Exp. Pharmacol. Physiol. 24, 235-242. \par

Shimada A., Ohta A., Akiguchi I., and Takeda T. (1993) Age-related deterioration in condition avoidance taks in the SAM-P/10 mouse, an animal model for spontaneous brain atrophy. Brain Res. 608, 266-272. \par

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory