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Inbred Strains of Mice: RLC


Inbr. F20+?. Albino. Genet. rlc/rlc. Origin: A spontaneous autosomal recessive mutation with rupture of the lens capsule and dislocation of the lens nucleus, designated rlc occurred in the CXSN/A strain. This was crossed with BALB/c followed by more than 20 generations of sib mating.


Opacity of the lens of both eyes develops spontaneously at 35-60 days of age. Histologically there is irregular swelling, condensation, degeneration and fragmentation of lens fibers in the deep cortex, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus dislocates behind the lens or occasionally in the anterior chamber (Iida et al, 1997). The gene maps to the middle section of chromosome 14 near D14Mit39 at about position 30.0 (Matsushima et al, 1996).

Iida F., Matsushima Y., Hiai H., Uga S., and Honda Y. (1997) Rupture of lens cateract: a novel hereditary recessive cateract model in the mouse. Exp. Eye Res. 64, 107-113. \par

Matsushima Y., Kamoto T., Iida F., Abujiang P., Honda Y., and Hiai H. (1996) Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics 36, 553-554. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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