of Mice: RIII
Inbr 80+. Albino: A,c.
Origin: Dobrovolskaia-Zavadskaia, Inst.
du Radium, Paris 1928, then see below. High mammary tumour incidence in
The following substrains are recognised:
Origin as above.
Dobrovolskaia-Zavadskaia to Andervont.
From Severi (Perugia) to Muhlbock (Amsterdam) 1964. Differs from the other
substrains at the Hbb
Short latency to emerge from home cage (2/7), high rearing in Y-maze (2/7),
high hole-in-the-wall entries (1/7), high exploration in Y-maze (2/7),
high number of stairs climbed (2/7) and low urination score (7/7) (McClearn et al., 1970
Life-span and spontaneous disease
Long life-span in conventional conditions (19/22 = 685 days in males, 16/22
= 655 days in females) (Storer, 1966). High
incidence (88%) of mammary tumours in breeding females (Heston,
1963), but a low proportion are of the acinar type (7/7) (Tengbergen,
1970). Ovarian tumours 60% in breeding females, 50% in virgin females
(Murphy, 1966). Mammary tumours 96% at 9 months
(Schlom et al., 1973., 1973), 70% at 12
months (Seman and Dmochowski, 1973). Has
been known to loose the mammary tumour virus spontaneously (Andervont and Dunn, 1962).
Normal physiology and biochemistry
High plasma cholinesterase activity (6/22 in females, 4/22 in males) (Angel et al., 1967., 1967). Mammary gland
sensitive to oestradiol and progesterone (1/7) (Singh
et al., 1970., 1970). High brain cholinesterase activity (1/5) (Pryor et al., 1966., 1966).
Small kidney/body weight ratio (18/21) (Schlager,
). Low total leukocyte count (17/18), low erythrocyte count (15/18),
high mean corpuscular volume (4/18) (Russell
et al., 1951
., 1951). High proportion of basophilic cells in adenohypophysis
(1/5) (Keramidas and Symeonidis, 1973
Adrenal gland has a small X zone (8/8), with a low incidence of vacuolisation
(6/6) (Delost and Chirvan-Nia, 1958
Sensitive to X-irradiation (24/27) (Roderick, 1963
Low susceptibility to endotoxin lipopolysaccharide (5/5) (Heppner and Weiss, 1965
High lymphocyte phytohaemagglutinin response (5/43) (Heiniger et al., 1975
., 1975). Erythrocytes have a high
agglutinability (cf. 14/25) (Rubinstein
et al., 1974
Poor reproductive performance (7/8), litter size 6.1 _ 0.2 and sterility
31% (Nagasawa et al., 1973
In 1967 both RIII and RIII/An maintained at The Jackson Laboratory failed
to produce viable young. RIII/2J was developed from a cross between the
two substrains. Name later changed to RIIIS. High serum complement activity
(c.f. 8/26) (Ong et al 1989)
RIIIS carries no detectable endogenous ecotropic MuLV DNA sequences (Jenkins et al 1982
). High ED50 to behavioural
effects of nicotine (16/19) (Marks et al 1989
Has the largest known deletion of the T cell receptor (TCR) V beta genes,
having lost approximately 130 kb of V beta chromosome and with it 13 V
beta genes out of the known 21 V beta genes of the TCR. The deletion is
marked by the presence of V beta 10 gene upstream and V beta 3 gene downstream.
(Haqqi et al 1989
Develops a condition resembling human type I von Willebrand's disease characterised
by a prolonged bleeding time, normal von Willebrand factor multimer (VWF)
distribution, autosomal dominant inheritance and proportionally decreased
plasma von Willebrand factor antigen and factor VIII activity. The disease
is caused by a genetic defect at a locus distinct from the murine von
Willebrand factor gene (Nichols et al, 1994).
A single dominant modifier locus (Mvwf) on distil chromosome
11 accounted for 63% of variation in plasma VWF levels in a cross with
CASA/Rk. This is distinct from the Vwf locus on chromosome 6
(Mohlke et al, 1996).
Resistant to the induction of arthritis by type II collagen (Ortman et al, 1994). Carries two mutations causing defects
in cortosteroid-binding globulin (Orava et
H. B. and Dunn T. B. (1962) Studies of the mammary tumor agent of strain
RIII mice. J. Natl. Cancer Inst. 28, 159-185.
R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability
of plasma cholinesterase activity in inbred mouse strains. Science
P. and Chirvan-Nia P. (1958) Differences raciales dans l'involution de
la zone x multi surrenalienne chez la souris adulte vierge. C. R.
Soc. Biol. 152, 453-455.
M., Banerjee S., Anderson G. D., and David C. S. (1989) RIII S/J (H-2r).
An inbred mouse strain with a massive deletion of T cell receptor V beta
genes. J. Exp. Med. 169, 1903-1909.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
G. and Weiss D. W. (1965) High susceptibility of strain A mice to endotoxin
and endotoxin-red blood cell mixtures. J. Bacteriol. 90,
Heston W. E. (1963)
Genetics of neoplasia, in Methodology in mammalian genetics (Burdette
W. J., ed), pp. 247-268. Holden-Day, San Francisco.
N. A., Copeland N. G., Taylor B. A., and Lee B. K. (1982) Organization,
distribution, and stability of endogenous ecotropic murine leukemia virus
DNA sequences in chromosomes of Mus musculus. J. Virol. 43,
G. D. and Symeonidis A. (1973) Characteristic microscopic differences
in the adenohypophysis of high and low mammary tumour strains of mice.
Pathol. Eur. 8, 35-36.
J., Stitzel J. A., and Collins A. C. (1989) Genetic influences on nicotine
responses. Pharmacol. Biochem. Behav. 33, 667-678.
G. E., Wilson J. R., and Meredith W. (1970) The use of isogenic and heterogenic
mouse stocks in behavioral research, in Contribution to behavior genetic
analysis. The mouse as a prototype (Lindzey G. and Thiessen D. D.,
eds), pp. 3-32. Appleton-Century-Crofts, New York.
K. L., Nichols W. C., Westrick R. J., Novak E. K., Cooney K. A., Swank
R. T., and Ginsburg D. (1996) A novel modifier gene for plasma von Willebrand
factor level maps to distal mouse chromosome 11. Proceedings of the
National Academy of Sciences of the United States of America 93,
Murphy E. D. (1966)
Characteristic tumors, in Biology of the laboratory mouse, 2nd. ed.
(Green E. L., ed), pp. 521-562. McGraw-Hill, New York.
H., Miyamoto M., and Fujimoto M. (1973) Reproductivity in inbred strains
of mice and project for their efficient production. Exp. Animals (Japan)
W. C., Cooney K. A., Mohlke K. L., Ballew J. D., Yang A., Bruck M. E.,
Reddington M., Novak E. K., Swank R. T., and Ginsburg D. (1994) von Willebrand
disease in the RIIIS/J mouse is caused by a defect outside of the von
Willebrand factor gene. Blood 83, 3225-3231.
Ong G. L. and
Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement
activity. J. Immunol. Methods 125, 147-158.
Zhao X. F., Leiter E., and Hammond G. L. (1994) Structure and chromosomal
location of the gene encoding mouse corticosteroid-binding globulin: Strain
differences in coding sequence and steroid-binding activity. Gene
R. A., Holderbaum D., Qu X. M., Banerjee S., and Haqqi T. M. (1994) BUB/BnJ
(H-2(q)) is a TCR deletion mutant mouse strain (TCR Vbetaa, KJ16- ) that
is susceptible to type II collagen-induced arthritis. J. Immunol.
T., Schlesinger K., and Calhoun W. H. (1966) Differences in brain enzymes
among five inbred strains of mice. Life Sci. 5, 2105-2111.
Roderick T. H.
(1963) The response of twenty-seven inbred strains of mice to daily doses
of whole-body X-irradiation. Radiation Res. 20, 631-639.
P., Liu N., Strenn E. W., and Decary F. (1974) Electrophoretic mobility
and agglutinability of red blood cells: a `new' polymorphism in mice.
J. Exp. Med. 139, 313-322.
E. S., Neufeld E. F., and Higgins C. T. (1951) Comparison of normal blood
picture of young adults from 18 inbred strains of mice. Proc. Soc.
Exp. Biol. Med. 78, 761-766.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
J., Michalides R., Kufe D., Hehlmann R., Spiegelman S., Bentvelzen P.,
and Hageman P. (1973) A comparative study of the biological and molecular
basis of murine mammary carcinoma. A model for human breast cancer. J.
Natl. Cancer Inst. 51, 541-551.
and Dmochowski L. (1973) Viropexis of type B particles in reticulum cell
sarcoma of RIII/Om strain mice. Cancer Res. 33, 1238-1246.
V., DeOme K. B., and Bern H. A. (1970) Strain differences in response
of the mouse mammary gland to hormones in vitro. J. Natl. Cancer Inst.
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
W. J. P. R. van E. (1970) Morphological classification of mammary tumours
in the mouse. Path. Eur. 5, 260-272.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,