of Mice: RFM
Inbr 120 +. Albino a,c.
Origin: Furth, to Oak Ridge 1949. Strain
has been found to be segregating for H2f
and substrains also
differ in other respects, so genetic contamination of some substrains
must be suspected. Maint. by N.
Leukaemia low (5%), but highly susceptible to induction of both myeloid
and lymphoid leukaemia by X-irradiation and chemical carcinogens (Walburg and Cosgrove, 1971
). Spalding and Brooks (1971
) found that the strain was segregating for H2k
Two substrains were
developed with a mean life-span of 655 _ 8 days in the H2k
substrain and 604 _ 10 days in the H2f
substrain, implying that the H2
locus may affect survival.
The substrains also differed in radiation resistance and spontaneous activity.
The presence of genetic variation within this strain may imply that some
substrains have become genetically contaminated by a non-strain mating.
Develops a spontaneous myelogenous leukaemia that is transplantable into
non-leukaemic mice of the same strain (Huseini
et al., 1976
., 1976). Reticulum cell sarcomas 57% in males and 70%
in females. Lung tumours 24% in males and 19% in females, and non-neoplastic
moderate to severe glomerular lesions in more than 50% of animals (Zurcher
S., Fried W., Knospe W. H., and Trobaugh F. E. Jr. (1976) Dynamics of
leukaemia and normal stem cells in leukaemic RFM mice. Cancer Res.
J. F. and Brooks M. R. (1971) The possible influence of a single gene
locus on lifespan and its relationship to radiation resistance and activity.
Proc. Soc. Exp. Biol. Med. 136, 1091-1093.
H. E. and Cosgrove G. E. (1971) Methycholanthrene-induced neoplasms in
germfree RFM mice. Int. J. Cancer 8, 338-343.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,