of Mice: PRO
Inbr: F61 (Brk). Genet: a, cch, p.
Origin: E. S. Russell, 129/ReJ x C57BL/6J. Sib-mating with selection for
Mutation to Pro1b
which controls activity level of proline oxidase in liver, kidney, and
brain, which is about 20% of normal in this strain. 7 and 50 fold elevation
of proline in blood and urine, respectively.
Hyperprolinaemia and prolinuria with increased taurine excretion (Blake et al., 1974
., 1974); sluggish movements, 50% generalised
hair loss (Kanwar et al., 1975
Hyperprolinaemia due to a deficiency in the activity of component 1 of
mitochondrial proline dehydrogenase (Blake
et al., 1976
., 1976), and associated with a decreased liver proline
oxidase activity (Blake, 1972
). High lymphocyte
phyto-haemagglutinin response (8/43) (Heiniger
et al., 1975
L., Grillo R. V., and Russell E. S. (1974) Increased taurine excretion
in hereditary hyperprolinemia of the mouse. Life Sci. 14,
L., Hall J. G., and Russell E. S. (1976) Mitochondrial proline dehydrogenase
deficiency in hyperprolinemic PRO/Re mice: Genetic and enzymatic analyses.
Biochem. Genet. 14, 739-757.
Blake R. L. (1972) Animal
model for hyperprolinaemia: deficiency of mouse proline oxidase activity.
Biochem. J. 129, 987-989.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Y. S., Krakower C. A., Manaligod J. R., Justice P., and Wong P. W. K.
(1975) Biochemical, morphological and hybrid studies in hyperprolinemic
mice. Biomedicine 22, 209-216.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,