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Inbred Strains of Mice: PRO


Inbr: F61 (Brk). Genet: a, cch, p. Origin: E. S. Russell, 129/ReJ x C57BL/6J. Sib-mating with selection for a, cch and p. Mutation to Pro1b (proline oxidase-1) which controls activity level of proline oxidase in liver, kidney, and brain, which is about 20% of normal in this strain. 7 and 50 fold elevation of proline in blood and urine, respectively.


Hyperprolinaemia and prolinuria with increased taurine excretion (Blake et al., 1974., 1974); sluggish movements, 50% generalised hair loss (Kanwar et al., 1975., 1975). Hyperprolinaemia due to a deficiency in the activity of component 1 of mitochondrial proline dehydrogenase (Blake et al., 1976., 1976), and associated with a decreased liver proline oxidase activity (Blake, 1972). High lymphocyte phyto-haemagglutinin response (8/43) (Heiniger et al., 1975., 1975).

Blake R. L., Grillo R. V., and Russell E. S. (1974) Increased taurine excretion in hereditary hyperprolinemia of the mouse. Life Sci. 14, 1285-1290. \par

Blake R. L., Hall J. G., and Russell E. S. (1976) Mitochondrial proline dehydrogenase deficiency in hyperprolinemic PRO/Re mice: Genetic and enzymatic analyses. Biochem. Genet. 14, 739-757. \par

Blake R. L. (1972) Animal model for hyperprolinaemia: deficiency of mouse proline oxidase activity. Biochem. J. 129, 987-989. \par

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831. \par

Kanwar Y. S., Krakower C. A., Manaligod J. R., Justice P., and Wong P. W. K. (1975) Biochemical, morphological and hybrid studies in hyperprolinemic mice. Biomedicine 22, 209-216. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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