of Mice: PN
Inbr 52. Albino c.
Origin: Albino mice from pet shop in New Zealand
in 1948. From Palmerston North Hosp. to Massey Univ. as 'NOS outbred'.
To Glaxo Labs of New Zealand as 'GW outbred'. Back to Palmerston North
as 'PN'. Maintained by Wigley in Med. Res Dept. and inbred starting in
1964, with selection for positive ANA (anti nuclear antibody) in first
Antinuclear antibodies appear at about 5 months, and 80% are positive
by 10 months. Develops lupus erythematosus with glomerular depositis of
IgG, IgM and IgA (Wigley et al., 1975
1975). Maint. by Hm, Mac.
R. D., Craig A. S., Williamson K. I., and Couchman K. G. (1975) Spontaneous
arteritis and glomerulitis in mice: a comparison of light and electron
microscope renal changes in PN/n, NZB/Bl, 101/Mac and CBA/Mac mice. Lab.
Invest. 33, 8-15.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,