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Inbred Strains of Mice: PBB


Inbr: F20+. Black. Genet: a. Origin: P. C. Bailey from multicoloured pet shop stock, in about 1972.


Become obese on a standard diet. Maximum body weight of about 65-75g is achieved at about 12 months. Blood glucose normal, but glucose tolerance abnormal. Serum insulin elevated. No histological abnormalities of pancreatic islets seen, although mild fatty infiltration of the liver is common. Breeding performance good and life-span normal (18-22 months). Obesity may be analogous to mature onset obesity in man (Hunt et al., 1972., 1972), and equivalent in many respects to the mutants ob (obese) and Ay (yellow) and the NZO inbred strain. The diabetes in this case has a polygenic mode of inheritance (Hunt et al., 1976., 1976).

Hunt C. E., Lindsey J. R., MaxField L. M., and Fox O. J. (1972) Obesity in a new strain of mouse. Fed. Proc. 31, 244. \par

Hunt C. E., Lindsey J. R., and Walkley S. U. (1976) Animal models of diabetes and obesity, including the PBB/Ld mouse. Fed. Proc. 35, 1206-1217. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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