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Inbred Strains of Mice: P

P/A

Inbr: 91. Origin: P. Kortweg 1934; DBA female x C57BL male, then N20 to C57BL, then b x s inbred.

P/J

Inbr: F153. Pink-eyed fawn. Genet: a, b, d, p, rd, se. Origin: Snell from a cross involving strain BDP. Carries the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, 129/J and FS/Ei) (Brilliant et al, 1994)


Characteristics

Lymphatic leukaemia 22% in males and 29% in breeding, and 58% in virgin females. Primary lung tumours zero in males and 3% in females (Hoag, 1963). Life-span short (3/22 = 384 days in males and 8/22 = 510 days in females) in conventional conditions (Storer, 1966). Low metabolic rate (15/18) (Storer, 1967). High serum ceruloplasmin levels in females (4/27) (Meier and MacPike, 1968). High susceptibility to audiogenic and electroconvulsive seizures (1/6) (Deckard et al., 1976., 1976). Large brain weight (15/18 in males, 14/18 in females) (Storer, 1967). Large brain/body weight ratio (1/20) and large spinal cord (2/25) (Roderick et al., 1973., 1973). Resistant to X-irradiation (5/27) (Roderick, 1963). Short survival in 90% oxygen (3/10) (Lieberman and Kellog, 1967). Low lymphocyte phytohaemagglutinin response (37/43) (Heiniger et al., 1975., 1975). Intermediate breeding performance (15/24) (Hansen et al., 1973., 1973). \par

High degree of genetic distinctiveness (8/27) (Taylor, 1972). Susceptible to colon carcinogenesis by 1,2-dimethylhydrazine (cf. 3/7) (Evans et al., 1977., 1977).


Brilliant M. H., Ching A., Nakatsu Y., and Eicher E. M. (1994) The original pink-eyed dilution mutation (p) arose in asiatic mice: Implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains. Genetics 138, 203-211. \par

Deckard B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental patterns of seizure susceptibility in inbred strains of mice. Devel. Psychobiol. 9, 17. \par

Evans J. T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1, 2-dimethylhydrazine. Cancer Res. 37, 134-136. \par

Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalog of NIH rodents. National Institutes of Health. DHEW publication (NIH) 74-606, Bethesda. \par

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831. \par

Hoag W. G. (1963) Spontaneous cancer in mice. Ann. NY Acad. Sci. 108, 805-831. \par

Lieberman J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator activity in various strains of mice. Pediatrics 39, 75-81. \par

Meier H. and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med. 128, 1185-1190. \par

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353. \par

Roderick T. H. (1963) The response of twenty-seven inbred strains of mice to daily doses of whole-body X-irradiation. Radiation Res. 20, 631-639. \par

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409. \par

Storer J. B. (1967) Relation of lifespan to brain weight, body weight and metabolic rate among inbred mouse strains. Exp. Gerontol. 2, 173-182. \par

Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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