of Mice: P
Inbr: 91. Origin: P. Kortweg 1934; DBA female x C57BL male, then N20 to
C57BL, then b x s inbred.
Inbr: F153. Pink-eyed fawn. Genet: a, b, d, p, rd, se.
Snell from a cross involving strain BDP. Carries the pink-eyed dilution
, which is derived from Asian mice of the Mus musculus
type (see also strains SJL, 129/J and FS/Ei) (Brilliant
et al, 1994
Lymphatic leukaemia 22% in males and 29% in breeding, and 58% in virgin
females. Primary lung tumours zero in males and 3% in females (Hoag,
). Life-span short (3/22 = 384 days in males and 8/22 = 510 days
in females) in conventional conditions (Storer,
). Low metabolic rate (15/18) (Storer,
). High serum ceruloplasmin levels in females (4/27) (Meier and MacPike, 1968
). High susceptibility to audiogenic
and electroconvulsive seizures (1/6) (Deckard
et al., 1976
., 1976). Large brain weight (15/18 in males, 14/18 in
females) (Storer, 1967
). Large brain/body weight
ratio (1/20) and large spinal cord (2/25) (Roderick
et al., 1973
., 1973). Resistant to X-irradiation (5/27) (Roderick,
). Short survival in 90% oxygen (3/10) (Lieberman and Kellog, 1967
). Low lymphocyte phytohaemagglutinin
response (37/43) (Heiniger et al., 1975
1975). Intermediate breeding performance (15/24) (Hansen et al., 1973
High degree of genetic distinctiveness (8/27) (Taylor,
1972). Susceptible to colon carcinogenesis by 1,2-dimethylhydrazine
(cf. 3/7) (Evans et al., 1977., 1977).
M. H., Ching A., Nakatsu Y., and Eicher E. M. (1994) The original pink-eyed
dilution mutation (p) arose in asiatic mice: Implications for the H4 minor
histocompatibility antigen, Myod1 regulation and the origin of inbred
strains. Genetics 138, 203-211.
B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental
patterns of seizure susceptibility in inbred strains of mice. Devel.
Psychobiol. 9, 17.
T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka
T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1,
2-dimethylhydrazine. Cancer Res. 37, 134-136.
C. T., Judge F. J., and Whitney R. A. (1973) Catalog of NIH rodents.
National Institutes of Health. DHEW publication (NIH) 74-606, Bethesda.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Hoag W. G. (1963) Spontaneous
cancer in mice. Ann. NY Acad. Sci. 108, 805-831.
J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator
activity in various strains of mice. Pediatrics 39, 75-81.
and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin
activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med.
T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic
and phenotypic variation in weight of brain and spinal cord between inbred
strains of mice. Brain Res. 64, 345-353.
Roderick T. H.
(1963) The response of twenty-seven inbred strains of mice to daily doses
of whole-body X-irradiation. Radiation Res. 20, 631-639.
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
Storer J. B. (1967)
Relation of lifespan to brain weight, body weight and metabolic rate among
inbred mouse strains. Exp. Gerontol. 2, 173-182.
Taylor B. A. (1972)
Genetic relationship between inbred strains of mice. J. Hered.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,