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Inbred Strains of Mice: NZY


Inbr: F120 (Wehi). Cinnamon piebald (?). Genet: b, s. Origin: see NZB; a piebald male appeared at F2 which was mated with a tan sister; at F4 a piebald brother-sister appeared; b x s mating with selection for piebald gene, s led to fixation of the coat pattern at F7.


High incidence of mammary tumours and pituitary adenomas. Megacolon 10%, associated with the s gene (Bielschowsky and Schofield, 1962). Highly susceptible to induction of connective tissue tumours by 4-nitroquinone N-oxide (1/5) (Searle and Spencer, 1966). A subline has been developed: NZYf/Bu Inbr: 65 since fostering. Origin: NZY at F26 were fostered on NZC. A marked reduction in mammary cancer but pituitary tumour incidence unchanged.

Bielschowsky M. and Schofield G. C. (1962) Studies on megacolon in piebald mice. Aust. J. Exp. Biol. Med. Sci. 40, 395-404.

Searle C. E. and Spencer A. T. (1966) Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin. Brit. J. Cancer 20, 877-885.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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