of Mice: NZY
Inbr: F120 (Wehi). Cinnamon piebald (?). Genet: b, s.
see NZB; a piebald male appeared at F2 which was mated with a tan sister;
at F4 a piebald brother-sister appeared; b x s mating with selection for
piebald gene, s
led to fixation of the coat pattern at F7.
High incidence of mammary tumours and pituitary adenomas. Megacolon 10%,
associated with the s
and Schofield, 1962
). Highly susceptible to induction of connective
tissue tumours by 4-nitroquinone N
-oxide (1/5) (Searle and Spencer, 1966
). A subline has been developed:
NZYf/Bu Inbr: 65 since fostering. Origin: NZY at F26 were fostered on
NZC. A marked reduction in mammary cancer but pituitary tumour incidence
M. and Schofield G. C. (1962) Studies on megacolon in piebald mice. Aust.
J. Exp. Biol. Med. Sci. 40, 395-404.
C. E. and Spencer A. T. (1966) Induction of tumours of connective tissue
by repeated applications of 4-nitroquinoline N-oxide to mouse skin. Brit.
J. Cancer 20, 877-885.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,