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Inbred Strains of Mice: NSY


Inbr F47 (Sept. 1996). Albino. Origin: From Jcl:ICR mice in 1975 with selective breeding for glucose intolerance. Develop spontaneous non-insulin-dependent diabetes mellitus in an age-dependent manner, reaching 98% in males and 31% in females at 48 weeks of age. Neither severe obesity nor extreme hyperinsulinemia is seen at any age (Ueda et al, 1995).

Ueda H., Ikegami H., Yamato E., Fu J., Fukuda M., Shen G., Kawaguchi Y., Takekawa K., Fujioka Y., Fujisawa T., Nakagawa Y., Hamada Y., Shibata M., and Ogihara T. (1995) The NSY mouse: A new animal model of spontaneous NIDDM with moderate obesity. Diabetologia 38, 503-508. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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