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Inbred Strains of Mice: NMRI


Inbr: F50 (Lac). Albino. Genet: c. Origin: Non-inbred Swiss mice from Lynch to Poiley 1937. Inbred by Poiley known as NIH/PI. To US Naval Med. Res. Inst. at F51, known as NMRI (but not histocompatible on arrival at Laboratory Animals Centre). NOTE: Many colonies of NMRI, particularly European, are random or pen-bred.


Poor water-escape learning (5/6) (Festing, 1973b). Low preference for sweet tasting substances (saccharin, sucrose, dulcin and acesulfame, averaged) (26/26) (Lush 1988). High brain glutamic acid decarboxylase (1/10) (Gaitonde and Festing, 1976). Short sleeping time under hexobarbital anaesthetic in females (4/15) (Lovell, 1976), short sleeping time under pentobarbitone anaesthetic (5/23), Lovell (1986). Good primary immune response to bacteriophage fd (1/7) (outbred) (Kolsch et al., 1971). Good reproductive performance (1/25) with colony output 1.5 young/female/week and litter size 7.3 (1/25) (Festing, unpublished).

Gaitonde M. K. and Festing M. F. W. (1976) Brain glutamic acid decarboxylase and open field activity in ten inbred strains of mice. Brain Res. 103, 617-621.

Lovell D.P. (1986) Variation in pentobarbitone sleeping time in mice. I. strain and sex differences. Lab. Anim. 20, 85-90.

Lush I.M. (1988) The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet. Res. 53, 95-99.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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