of Mice: NMRI
Inbr: F50 (Lac). Albino. Genet: c
. Origin: Non-inbred Swiss mice
from Lynch to Poiley 1937. Inbred by Poiley known as NIH/PI. To US Naval
Med. Res. Inst. at F51, known as NMRI (but not histocompatible on arrival
at Laboratory Animals Centre). NOTE: Many colonies of NMRI, particularly
European, are random or pen-bred.
Poor water-escape learning (5/6) (Festing, 1973b). Low preference for sweet
tasting substances (saccharin, sucrose, dulcin and acesulfame, averaged)
(26/26) (Lush 1988
). High brain glutamic acid
decarboxylase (1/10) (Gaitonde and Festing,
). Short sleeping time under hexobarbital anaesthetic in females
(4/15) (Lovell, 1976), short sleeping time under pentobarbitone anaesthetic
(5/23), Lovell (1986
). Good primary immune response
to bacteriophage fd (1/7) (outbred) (Kolsch et al
., 1971). Good
reproductive performance (1/25) with colony output 1.5 young/female/week
and litter size 7.3 (1/25) (Festing, unpublished).
M. K. and Festing M. F. W. (1976) Brain glutamic acid decarboxylase and
open field activity in ten inbred strains of mice. Brain Res.
Lovell D.P. (1986)
Variation in pentobarbitone sleeping time in mice. I. strain and sex differences.
Lab. Anim. 20, 85-90.
Lush I.M. (1988) The genetics
of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet.
Res. 53, 95-99.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,