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Inbred Strains of Mice: NIH


Inbr (Ola) ?+27. Albino: a,b,c. Origin: Pitman at NIH from N:NIH(S) stock to Natl. Inst. Biol. Standards, Hampstead, England in 1968. To Burroughs Welcome 1970 and Ola in 1975.


Good reproductive performance, and able to breed at high ratios of females per male (Peters and Festing 1985). Carries gene rd causing retinal degeneration (Stirling et al 1983i0 1983). Highly susceptible to infection with the helminth Mesocestoides corti . Larval burdens at 21 days after infection with 100 tetrathyridia being considerably higher (greater than 1000) than all other strains except SJL, which was comparable. (Lammas et al 1990). Maint. by Ola

Lammas D. A., Mitchell L. A., and Wakelin D. (1990) Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoides corti. Parasitology 101, 291-299. \par

Peters A. G. and Festing M. F. W. (1985) NIH/Ola: a highly productive inbred strain of the laboratory mouse. Lab. Anim. 19, 320-327. \par

Stirling P., Tullo A. B., Blyth W. A., and Hill T. J. (1983) Retinal degeneration in NIH (inbred) mice. Exp. Eye Res. 36, 761-763. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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