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Inbred Strains of Mice: MSM


Inbr. 20. White-bellied agouti Aw,b,c. Origin: Wild mice trapped in Mishima City, Shizuoka Prefecture, Japan and inbred in 1979 by Moriwaki. Has not been crossed with laboratory mice. Previously called M.MOL-MSM. Resistant to the development of lymphoma, due to at least two loci in crosses involving strain SL/Kh (Pataer et al, 1996). Fibroblast-like cells from the brains of these mice immortalise in tissue culture in a similar way to those of other strains (Yuasa et al, 1996). C3HxMSM F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous cell carcinomas of the forestomach with about 20% and 15% having mutations in H-ras and p53, respectively (Masui et al, 1997).

Masui T., Tezuka N., Nakanishi H., Inada K. I., Miyashita N., and Tatematsu M. (1997) Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Cancer Lett. 111, 97-104. \par

Pataer A., Kamoto T., Lu L. M., Yamada Y., and Hiai H. (1996) Two dominant host-resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 56, 3716-3720. \par

Yuasa T., Abe E., Oshimura M., and Namba M. (1996) Immortalization of cells from brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Acta Medica Okayama 50, 319-324. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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