High susceptibility of MRL-lpr to Mycobacterium leprae (contrast NOD) (Yogi et al 1989). Molecular heterogeneity of auto-anti-idiotypic antibodies has been studied by Koisumi et al (1991).
Develop a mild spontaneous arthritis which can be enhanced by intradermal injection of complete Freund's adjuvant. This appears to be due largely to background genes rather than lpr (Ratkay et al, 1994).
Embryonic stem cell lines have been established (Kawase et al, 1994).
MRL/Mp-+/+ mice develop pancreatitis and sialoadenitis from seven months of age and also drastic thymic involution. Transplantation of allogeneic foetal thymus (from C57BL/6 mice) plus either foetal bone marrow or hematopoetic cells resulted in normal T and B cell function, and the pancreatitis and sialoadenitis was also fully corrected (Hosaka et al, 1996).
Maint. by J, Ola.
Halpern M. D. and Yocum D. E. (1991) The paradoxical effects of diethyldithiocarbamate: comparisons between New Zealand black/white F1 hybrid and Balb/c mice. Clin. Immunol. Immunopathol. 58, 69-79. \par
Hosaka N., Nose M., Kyogoku M., Nagata N., Miyashima S., Good R. A., and Ikehara S. (1996) Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice. Proceedings of the National Academy of Sciences of the United States of America 93, 8558-8562. \par
Huang F. P., Feng G. J., Lindop G., Stott D. I., and Liew F. Y. (1996) The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. Journal Of Experimental Medicine 183, 1447-1459. \par
Jabs D. A., Burns W. H., and Prendergast R. A. (1996) Paradoxic effect of anti-CD4 therapy on lacrimal gland disease in MRL/Mp-lpr/lpr mice. Investigative Ophthalmology & Visual Science 37, 246-250. \par
Kawase E., Suemori H., Takahashi N., Okazaki K., Hashimoto K., and Nakatsuji N. (1994) Strain difference in establishment of mouse embryonic stem (ES) cell lines. International Journal of Developmental Biology 38, 385-390. \par
Manolios N., Geczy C. L., and Schrieber L. (1990) Aberrant lymphocyte migration patterns in systemic lupus erythematosus (MRL/l, MRL/n) mice are independent of the micro-environment. Autoimmunity 7, 139-148. \par
Murphy E. D. (1981) Lymphoproliferation (lpr) and other sinbgle-locus models for murine lupus, in Immunologic defects in laboratory animals Vol. I (Gershwin M. E. and Merchant B., eds), pp. 143-173. Plenum Press, New York,London. \par
Nabarra B., Dardenne M., and Bach J. F. (1990) Thymic reticulum of autoimmune mice. II: Ultrastructural studies of mice with lupus-like syndrome (NZB, BXSB, MRL/l). Journal of Autoimmunity 3, 25-36. \par
Ratkay L. G., Tait B., Tonzetich J., and Waterfield J. D. (1994) Lpr and MRL background gene involvement in the control of adjuvant enhanced arthritis in MRL-lpr mice. Journal of Autoimmunity 7, 561-573. \par
Spurney R. F., Onorato J. J., Ruiz P., Pisetsky D. S., and Coffman T. M. (1993) Characterization of glomerular thromboxane receptors in murine lupus nephritis. J. Pharmacol. Exp. Therapeut. 264, 584-590. \par
Theofilopoulos A. N., McConahey P. J., Izui S., Eisenberg R. A., Pereira A. B., and Creighton W. D. (1980) A comparitive immunologic analysis of several murine stains with autoimmune manifestations. Clin. Immunol. Immunopathol. 15, 258-278. \par
Yogi Y., Nakamura K., and Suzuki A. (1989) The experimental inoculation with Mycobacterium leprae in autoimmune mice: results of MRL/lpr mice inoculated into the right hind foot. Japanese Journal of Leprosy 58, 235-240. \par
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