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Inbred Strains of Mice: LST


Inbr (Bc) 63. Albino. Origin: A tabby/ circling stock from Oak Ridge circa 1957. To Katheryn F.Stein, Mount Holyoke College, Mass. to U.B.C., Vancouver in 1966 at F9. Homozygous for the lgStn gene resulting in 99% open-eyes at birth. Maint. by Bc.


Set of 27 recombinant inbred strains developed from a cross between outbred stocks SS and LS, selected for short and long sleeping times, respectively, under ethanol anaesthetic (McClearn and Kakihana, 1981). Mean sleeping time varies from 36 to 171 minutes in the 27 strains (DeFries et al 19890 1989). The set of strains has been characterised for sensitivity to pentobarbital, phenobarbital, and flurazepam as measured by sleep times (Wehner et al 1991), and for 118 SSLP genetic markers (Markel et al, 1996)

DeFries J. C., Wilson J. R., Erwin V. G., and Peterson D. R. (1989) LSXSS Recombinant inbred strains of mice: Initial characterization. Alcoholism: Clin. Exp. Res. 13, 196-200. \par

McClearn G. E. and Kakihana R. (1981) Selective breeding for ethanol sensitivity: short-sleep and long-sleep mice, in Development of animal models as pharmacogenetic tools, (DHHS publication No. ADM 81-1133) ed. (McClearn G. E., Deitrich R. A., and Erwin V. G., eds), pp. 147-159. Government Printing Office, Washington, DC. \par

Wehner J. M., Pounder J. I., and Bowers B. J. (1991) The use of recombinant inbred strains to study mechanisms of drug action. J. Addict. Dis. 10, 89-107. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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