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Inbred Strains of Mice: LP


Inbr (J) 125. Colour: white-bellied agouti with white patches Aw,s. Origin: Dunn 1928 from a chinchilla stock from Castle and some coat colour stocks from English fanciers. To Scott, to Dickie 1947, to J 1949. Maint. by J.


High emotionality (4/15) (Thompson, 1953). Susceptible to audiogenic seizures (1/11) (Fuller and Sjursen, 1967). Long life-span in conventional conditions (22/22 = 748 days in males, 22/22 = 799 days in females) (Storer, 1966). Overall tumour incidence 26% in males and 30% in females, with a wide range of tumour types, including mammary tumours (14% in females, 3% in males), lymphoma (1% in males, 8% in females), lung tumours (5% in males, 4% in females) and soft-tissue sarcomas (7% in males, 6% in females) (Smith et al. 1973). High plasma cholesterol at 12 and 24 weeks (1/8) (Weibust, 1973). High serum ceruloplasmin levels in females (5/27) and males (8/26) (Meier and MacPike, 1968). Low plasma cholinesterase activity in males (19/22) (Angel et al., 1967., 1967). Low hypoxanthene-guanine phosphoribosyl transferase in thalamus (7/7) (Suran, 1973). Low brain monoamine oxidase (6/7) and catechol-O-methyltransferase activity (7/7) (Tunnicliff et al., 1973., 1973). High mean heart rate adaptation (1/7) (Blizard and Welty, 1971). Large spinal cord (4/25) (Roderick et al., 1973., 1973). Small kidney/body weight ratio (17/21) (Schlager, 1968). Susceptible to skin ulceration by DMBA (cf. 13/22) (Thomas et al., 1973., 1973). Highly resistant to the induction of catalepsy by haloperidol (8/8) associated with midbrain dopamine D2 receptor density levels (Kanes et al, 1993)

Low retinal ganglion cell number (5/24) (Williams et al, 1996).

High lymphocyte phytohaemagglutinin response (9/43) (Heiniger et al., 1975., 1975). Poor immune response to ovomucoid, but good response to ovalbumin (cf. 6/12) (Vaz et al., 1971., 1971). Discriminator between `H' and `L' sheep erythrocytes (cf. 12/18) (McCarthy and Dutton, 1975). \par

Resistant to induction of diabetes mellitus by encephalomyocarditis virus (cf. 7/14) (Boucher et al., 1975., 1975).

Angel C. R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability of plasma cholinesterase activity in inbred mouse strains. Science 156, 529-530. \par

Blizard D. A. and Welty R. (1971) Cardiac activity in the mouse: strain differences. J. Comp. Physiol. Psychol. 77, 337-344. \par

Boucher D. W., Hayashi K., Rosenthal J., and Notkins A. L. (1975) Virus-induced diabetes mellitus. III. Influence of sex and strain of host. J. Infect. Dis. 131, 462-466. \par

Fuller J. L. and Sjursen F. H. (1967) Audiogenic seizures in eleven mouse strains. J. Hered. 58, 135-140. \par

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831. \par

Kanes S. J., Hitzemann B. A., and Hitzemann R. J. (1993) On the relationship between D2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice. J. Pharmacol. Exp. Therapeut. 267, 538-547. \par

McCarthy M. M. and Dutton R. W. (1975) The humoral response of mouse spleen cells to two types of sheep erythrocytes. J. Immunol. 115, 1316-1321. \par

Meier H. and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med. 128, 1185-1190. \par

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353. \par

Schlager G. (1968) Kidney weight in mice: strain differences and genetic determination. J. Hered. 59, 171-174. \par

Smith G. S., Walford R. L., and Mickey R. M. (1973) Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J. Natl. Cancer Inst. 50, 1195-1213. \par

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409. \par

Suran A. A. (1973) Hypoxanthine-guanine phorphoribosyl transferase in brains of mice. Regional distribution in seven inbred mouse strains. Life Sci. 13, 1779-1788. \par

Thomas P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74, 655-659. \par

Thompson W. R. (1953) The inheritance of behaviour: behavioural differences in fifteen mouse strains. Can. J. Psychol. 7, 145-155. \par

Tunnicliff G., Wimer C. C., and Wimer R. E. (1973) Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice. Brain Res. 61, 428-434. \par

Vaz N. M., Phillips-Quagliata J. M., Levine B. B., and Vaz E. M. (1971) H-2 linked genetic control of immune responsiveness to ovalbumin and ovomucoid. J. Exp. Med. 134, 1335-1348. \par

Weibust R. S. (1973) Inheritance of plasma cholesterol levels in mice. Genetics 73, 303-312. \par

Williams R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control of variation in retinal ganglion-cell number in mice. Journal of Neuroscience 16, 7193-7205. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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