of Mice: LP
Inbr (J) 125. Colour: white-bellied agouti with white patches Aw,s.
Origin: Dunn 1928 from a chinchilla stock from Castle and some coat colour
stocks from English fanciers. To Scott, to Dickie 1947, to J 1949. Maint.
High emotionality (4/15) (Thompson, 1953
Susceptible to audiogenic seizures (1/11) (Fuller
and Sjursen, 1967
). Long life-span in conventional conditions (22/22
= 748 days in males, 22/22 = 799 days in females) (Storer,
). Overall tumour incidence 26% in males and 30% in females, with
a wide range of tumour types, including mammary tumours (14% in females,
3% in males), lymphoma (1% in males, 8% in females), lung tumours (5%
in males, 4% in females) and soft-tissue sarcomas (7% in males, 6% in
females) (Smith et al. 1973
). High plasma
cholesterol at 12 and 24 weeks (1/8) (Weibust,
). High serum ceruloplasmin levels in females (5/27) and males
(8/26) (Meier and MacPike, 1968
). Low plasma
cholinesterase activity in males (19/22) (Angel
et al., 1967
., 1967). Low hypoxanthene-guanine phosphoribosyl transferase
in thalamus (7/7) (Suran, 1973
). Low brain
monoamine oxidase (6/7) and catechol-O
(7/7) (Tunnicliff et al., 1973
High mean heart rate adaptation (1/7) (Blizard
and Welty, 1971
). Large spinal cord (4/25) (Roderick et al., 1973
., 1973). Small kidney/body weight ratio
(17/21) (Schlager, 1968
). Susceptible to skin
ulceration by DMBA (cf. 13/22) (Thomas et
., 1973). Highly resistant to the induction of catalepsy
by haloperidol (8/8) associated with midbrain dopamine D2 receptor density
levels (Kanes et al, 1993
Low retinal ganglion cell number (5/24) (Williams
et al, 1996).
High lymphocyte phytohaemagglutinin response (9/43) (Heiniger et al., 1975., 1975). Poor immune response to
ovomucoid, but good response to ovalbumin (cf. 6/12) (Vaz et al., 1971., 1971). Discriminator between `H' and `L'
sheep erythrocytes (cf. 12/18) (McCarthy
and Dutton, 1975).
Resistant to induction of diabetes mellitus by encephalomyocarditis virus
(cf. 7/14) (Boucher et al., 1975., 1975).
R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability
of plasma cholinesterase activity in inbred mouse strains. Science
D. A. and Welty R. (1971) Cardiac activity in the mouse: strain differences.
J. Comp. Physiol. Psychol. 77, 337-344.
D. W., Hayashi K., Rosenthal J., and Notkins A. L. (1975) Virus-induced
diabetes mellitus. III. Influence of sex and strain of host. J. Infect.
Dis. 131, 462-466.
J. L. and Sjursen F. H. (1967) Audiogenic seizures in eleven mouse strains.
J. Hered. 58, 135-140.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
J., Hitzemann B. A., and Hitzemann R. J. (1993) On the relationship between
D2 receptor density and neuroleptic-induced catalepsy among eight inbred
strains of mice. J. Pharmacol. Exp. Therapeut. 267, 538-547.
M. M. and Dutton R. W. (1975) The humoral response of mouse spleen cells
to two types of sheep erythrocytes. J. Immunol. 115, 1316-1321.
and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin
activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med.
T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic
and phenotypic variation in weight of brain and spinal cord between inbred
strains of mice. Brain Res. 64, 345-353.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
S., Walford R. L., and Mickey R. M. (1973) Lifespan and incidence of cancer
and other diseases in selected long-lived inbred mice and their F1 hybrids.
J. Natl. Cancer Inst. 50, 1195-1213.
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
Suran A. A. (1973) Hypoxanthine-guanine
phorphoribosyl transferase in brains of mice. Regional distribution in
seven inbred mouse strains. Life Sci. 13, 1779-1788.
P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between
aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced
skin ulceration in mice. Genetics 74, 655-659.
Thompson W. R.
(1953) The inheritance of behaviour: behavioural differences in fifteen
mouse strains. Can. J. Psychol. 7, 145-155.
G., Wimer C. C., and Wimer R. E. (1973) Relationships between neurotransmitter
metabolism and behaviour in seven inbred strains of mice. Brain Res.
Vaz N. M., Phillips-Quagliata
J. M., Levine B. B., and Vaz E. M. (1971) H-2 linked genetic control of
immune responsiveness to ovalbumin and ovomucoid. J. Exp. Med.
Weibust R. S. (1973)
Inheritance of plasma cholesterol levels in mice. Genetics 73,
R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control
of variation in retinal ganglion-cell number in mice. Journal of Neuroscience
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,