of Mice: LG
Inbr (J) 104. Albino. Genet. a,c
Origin: Developed by Goodale
with selection for large body size begining in 1931 (Chai
). Two substrains, J and Ckc were separated at F27. LG/J is H2d,
while LG/Ckc is H2ar1,
LG/J should not be confused
with MacArthur's large strain which has never been established as an inbred
strain and is now extinct.
Mean life-span 491 days (Staats, 1976
5% incidence of bent or kinked tails (Dagg, 1966
Low kidney arylsulphatase activity (12/12) (Daniel,
). Large brain weight (1/25) and spinal cord (1/25) (Roderick et al., 1973
., 1973). High serum complement activity
(c.f. 8/26) (Ong et al 1989
). Low lymphocyte
phyto-haemagglutinin response (41/43) (Heiniger
et al., 1975
., 1975). Large number of granule cells in right area
dentata of brain (1/5) (Wimer and Wimer 1982
Maint. by J. Large body weight which differs from that of the small strain
SM/J as a result of about seven quantitative trait loci at one week and
17 loci at 10 weeks of age. Each locus has a small effect (Cheverud et al, 1996
J substrain develops antinuclear autoantibodies and rheumatoid factor,
and develop renal disease including glomerulonephritis, intersticial nephritis
and perivasculitis, but not hepatic or cutaneous disease. Strain MRL/Mp
has an estimated 75% of genome in common with this strain (Peng et al, 1996).
Chai C. K. (1961) Analysis
of quantitative inheritance of body size in mice. IV an attempt to isolate
polygenes. Genet. Res. 2, 25-32.
J. M., Routman E. J., Duarte F. A. M., Van Swinderen B., Cothran K., and
Perel C. (1996) Quantitative trait loci for murine growth. Genetics
Dagg C. P. (1966) Teratogenesis,
in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed),
pp. 309-328. McGraw-Hill, New York.
Daniel W. L. (1976)
Genetics of murine liver and kidney arylsulfatase B. Genetics
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
Ong G. L. and
Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement
activity. J. Immunol. Methods 125, 147-158.
Peng S. L.,
Madaio M. P., and Craft J. (1996) Systemic autoimmunity in LG/J mice.
Immunology Letters 53, 153-155.
T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic
and phenotypic variation in weight of brain and spinal cord between inbred
strains of mice. Brain Res. 64, 345-353.
Staats J. (1976) Standardized
nomenclature for inbred strains of mice: Sixth listing. Cancer Res.
E. and Wimer C. C. (1982) A geneticists map of the mouse brain, in Genetics
of the brain (Lieblich I., ed), pp. 395-420. Elsevier, Oxford.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,