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Inbred Strains of Mice: LG


Inbr (J) 104. Albino. Genet. a,c Origin: Developed by Goodale with selection for large body size begining in 1931 (Chai 1961). Two substrains, J and Ckc were separated at F27. LG/J is H2d, Pgk2b while LG/Ckc is H2ar1, Pgk2a. LG/J should not be confused with MacArthur's large strain which has never been established as an inbred strain and is now extinct.


Mean life-span 491 days (Staats, 1976). About 5% incidence of bent or kinked tails (Dagg, 1966). Low kidney arylsulphatase activity (12/12) (Daniel, 1976). Large brain weight (1/25) and spinal cord (1/25) (Roderick et al., 1973., 1973). High serum complement activity (c.f. 8/26) (Ong et al 1989). Low lymphocyte phyto-haemagglutinin response (41/43) (Heiniger et al., 1975., 1975). Large number of granule cells in right area dentata of brain (1/5) (Wimer and Wimer 1982) Maint. by J. Large body weight which differs from that of the small strain SM/J as a result of about seven quantitative trait loci at one week and 17 loci at 10 weeks of age. Each locus has a small effect (Cheverud et al, 1996).

J substrain develops antinuclear autoantibodies and rheumatoid factor, and develop renal disease including glomerulonephritis, intersticial nephritis and perivasculitis, but not hepatic or cutaneous disease. Strain MRL/Mp has an estimated 75% of genome in common with this strain (Peng et al, 1996).

Chai C. K. (1961) Analysis of quantitative inheritance of body size in mice. IV an attempt to isolate polygenes. Genet. Res. 2, 25-32.

Cheverud J. M., Routman E. J., Duarte F. A. M., Van Swinderen B., Cothran K., and Perel C. (1996) Quantitative trait loci for murine growth. Genetics 142, 1305-1319.

Dagg C. P. (1966) Teratogenesis, in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed), pp. 309-328. McGraw-Hill, New York.

Daniel W. L. (1976) Genetics of murine liver and kidney arylsulfatase B. Genetics 82, 477-491.

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831.

Ong G. L. and Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement activity. J. Immunol. Methods 125, 147-158.

Peng S. L., Madaio M. P., and Craft J. (1996) Systemic autoimmunity in LG/J mice. Immunology Letters 53, 153-155.

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353.

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377.

Wimer R. E. and Wimer C. C. (1982) A geneticists map of the mouse brain, in Genetics of the brain (Lieblich I., ed), pp. 395-420. Elsevier, Oxford.

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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