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Inbred Strains of Mice: Infection

Infection

Murine acquired immune deficiency (MAIDS) is an immunosuppressive disease of mice induced by infection with the LP-BM5 murine leukemia retrovirus. Strain BDP has a novel disease phenotype with recovery of immune function after a period of profound immune suppression. This is inherited as a dominant character in crosses with both susceptible and resistant strains (Gilmore, 1997).

Gilmore G. L. (1997) Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance of the 'regressor' phenotype. Immunol. 90, 7-13.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
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MGI 6.23 		The Jackson Laboratory
Inbred Strains of Mice: Infection

Infection

Resistant to polyoma virus-induced tumours due to a resistance gene Pyvr , which did not recombine with Mtv-7. Resistance can be overcome by irradiation, indicating an immunological basis (Lukacher et al, 1995). Resistant to Mycoplasma pulmonis infection (cf 4/16) (Cartner et al, 1996).

Reproduction

Intermediate breeding performance (12/25), colony output 0.98 young/female/week, litter size at weaning high at 6.5 (5/25) (Festing 1976a). Poor breeding performance (24/24) (Hansen et al., 1973., 1973). High ratio of females at birth (2/11) (Cook and Vlcek, 1961).

Miscellaneous

High degree of genetic distinctiveness (6/27) (Taylor, 1972). Recommended host for transplantable pituitary tumour BW8685 (Kaliss, 1972). High incidence of spontaneous `deviants' (possible mutations) (1/21) (Schlager and Dickie, 1967).

Cartner S. C., Simecka J. W., Briles D. E., Cassell G. H., and Lindsey J. R. (1996) Resistance to Mycoplasmal lung-disease in mice is a complex genetic trait. Infect. Immun. 64, 5326-5331.

Cook M. J. and Vlcek A. (1961) Sex ratio in mice. Nature 191, 89.

Gilmore G. L. (1997) Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance of the 'regressor' phenotype. Immunol. 90, 7-13.

Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalog of NIH rodents. National Institutes of Health. DHEW publication (NIH) 74-606, Bethesda.

Lukacher A. E., Ma Y., Carroll J. P., AbromsonLeeman S. R., Laning J. C., Dorf M. E., and Benjamin T. L. (1995) Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. Journal Of Experimental Medicine 181, 1683-1692.

Schlager G. and Dickie M. M. (1967) Spontaneous mutations and mutation rates in the house mouse. Genetics 57, 319-330.

Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory