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Inbred Strains of Mice: IF


Inbr: F70 (A). Black and tan. Genet: at . Origin: G. Bonser (Leeds) 1932-1936 by selection for formation of a `wart' after tar application.


Now more susceptible than five other strains (including BALB/c and CBA) to tar, methylcholanthrene and 3,4-benzpyrene. No spontaneous mammary tumours (Bonser, 1938). Susceptible to induction of brain tumours by N-ethyl-N-nitrosourea (Searle and Jones, 1972). High incidence of spontaneous pseudopregnancy. Maint. by A.

Bonser G. M. (1938) The hereditary factor in induced skin tumours in mice: establishment of a strain specially sensitive to carcinogenic agents applied to the skin. J. Pathol. Bacteriol. 46, 581-602. \par

Searle C. E. and Jones E. L. (1972) Tumours of the nervous system in mice treated neonatally with N-ethyl-N-nitrosourea. Nature 240, 559-560. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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